C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) A61K 39/00 (2006.01) C07K 16/30 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2411404
Compositions and methods for the therapy and diagnosis of cancer, particularly ovarian cancer, are disclosed. Illustrative compositions comprise one or more ovarian tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly ovarian cancer.
L'invention concerne des compositions et des méthodes permettant le traitement et le diagnostic du cancer, plus particulièrement du cancer de l'ovaire. Les compositions décrites dans cette invention comprennent un ou plusieurs polypeptides de tumeur ovarienne, une ou plusieurs parties immunogènes de ceux-ci, des polynucléotides codant pour de tels polypeptides, une cellule présentatrice d'antigène exprimant de tels polypeptides, et des lymphocytes T propres aux cellules exprimant de tels polypeptides. Ces compositions sont utiles, par exemple, pour le diagnostic, la prévention et/ou le traitement de maladies, en particulier, le cancer de l'ovaire.
Algate Paul A.
Harlocker Susan L.
Jones Robert
Corixa Corporation
Gowling Lafleur Henderson Llp
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