C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61P 35/00 (2006.01) C07H 21/00 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 19/00 (2006.01) C12N 15/62 (2006.01) G01N 33/566 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2411278
Compositions and methods for the therapy and diagnosis of cancer, such as colon cancer, are disclosed. Compositions may comprise one or more colon tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a colon tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as colon cancer. Diagnostic methods based on detecting a colon tumor protein, or mRNA encoding such a protein, in a sample are also provided.
L'invention concerne des compositions et des procédés pour la thérapie et le diagnostic du cancer, du type cancer du colon. Les compositions peuvent comprendre une ou plusieurs protéines de tumeur du colon, y compris leurs parties immunogènes, ou des polynucléotides codant ces parties. Selon une variante, une composition thérapeutique peut comprendre une cellule à antigène exprimant une protéine de tumeur du colon, ou une cellule T spécifique aux cellules exprimant ce type de protéine. On peut utiliser les compositions considérées, par exemple, pour la prévention et le traitement de maladies comme le cancer du colon. L'invention concerne également des procédés diagnostiques reposant sur la détection d'une protéine de tumeur du colon, ou de l'ARNm codant ladite protéine, dans un échantillon.
Clapper Jonathan D.
Hepler William T.
Jiang Yuqiu
Secrist Heather
Wang Aijun
Corixa Corporation
Gowling Lafleur Henderson Llp
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