Compositions and methods for the therapy and diagnosis of...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 35/14 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C07K 19/00 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/10 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01) A61K 35/12 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2403909

Compositions and methods for the therapy and diagnosis of cancer, particularly prostate cancer, are disclosed. Illustrative compositions comprise one or more prostate-specific polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly prostate cancer.

L'invention concerne des compositions et des méthodes de thérapie et de diagnostic du cancer, en particulier du cancer de la prostate. Des compositions servant d'illustration contiennent un ou plusieurs polypeptides spécifiques à la prostate, des portions immunogènes de ceux-ci, des polynucléotides codant ces polypeptides, une cellule de présentation d'antigène exprimant ces polypeptides, ainsi que des lymphocytes T spécifiques à des cellules exprimant ces polypeptides. Les compositions décrites sont utiles, par exemple, dans le diagnostic, la prévention et/ou le traitement de maladies, en particulier du cancer de la prostate.

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