Compositions and methods for the therapy and diagnosis of...

Details Compositions and methods for the therapy and diagnosis of... Compositions and methods for the therapy and diagnosis of...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 31/711 (2006.01) A61K 35/14 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) C07K 14/47 (2006.01) C07K 16/30 (2006.01) C12N 5/08 (2006.01) C12Q 1/68 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2404233

Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.

L'invention concerne des compositions et des méthodes pouvant traiter ou diagnostiquer le cancer, notamment le cancer du poumon. Des compositions exemplaires contiennent un ou plusieurs polypeptides de tumeur brocho-pulmonaire, des parties immunogènes desdits polypeptides, des polynucléotides codant ces polypeptides, une cellule antigénique exprimant ces polypeptides, et des lymphocytes T spécifiques de cellules exprimant ces polypeptides. Les compositions de l'invention sont utiles, par exemple, pour diagnostiquer, prévenir et/ou traiter des maladies, notamment le cancer du poumon.

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