Compositions and methods for the therapy and diagnosis of...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/12 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07K 14/47 (2006.01) C07K 16/30 (2006.01) C12N 15/62 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2410624

Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.

L'invention concerne des compositions et des méthodes de thérapie et de diagnostic du cancer, notamment du cancer du poumon. Des compositions démonstratives comprennent un ou plusieurs polypeptides de tumeur pulmonaire, des parties immunogènes de ces polypeptides, des polynucléotides qui codent pour de tels polypeptides, des cellules à présentation d'antigène qui expriment ces polypeptides, et des cellules T qui sont spécifiques des cellules exprimant de tels polypeptides. Les compositions de l'invention sont utiles notamment dans le diagnostic, la prévention et/ou le traitement de maladies, en particulier du cancer du poumon.

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