Compositions and methods for the therapy and diagnosis of...

Details Compositions and methods for the therapy and diagnosis of... Compositions and methods for the therapy and diagnosis of...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 5/10 (2006.01) C12N 15/62 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2409299

Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.

La présente invention concerne des compositions et procédés destinés à la thérapie et au diagnostic du cancer, en particulier du cancer du sein. Les principales compositions de l'invention comprennent un ou plusieurs polypeptides tumoraux du sein, certaines de leurs portions immunogènes, des polynucléotides codant de tels polypeptides, une cellule présentant un antigène et qui exprime de tels polypeptides, et des lymphocytes T spécifiques de cellules exprimant de tels polypeptides. Les compositions de l'invention conviennent notamment pour le diagnostic, la prévention et/ou le traitement d'affections, en particulier du cancer du sein.

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