C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61P 35/00 (2006.01) C07H 21/00 (2006.01) C07K 14/47 (2006.01) C07K 14/725 (2006.01) C07K 16/30 (2006.01) C07K 19/00 (2006.01) C12N 15/63 (2006.01)
Patent
CA 2418391
Compositions and methods for the therapy and diagnosis of cancer, such as ovarian cancer, are disclosed. Compositions may comprise one or more ovarian carcinoma proteins, immunogenic portions thereof, polynucleotides that encode such portions or antibodies or immune system cells specific for such proteins. Such compositions may be used, for example, for the prevention and treatment of diseases such as ovarian cancer. Methods are further provided for identifying tumor antigens that are secreted from ovarian carcinomas and/or other tumors. Polypeptides and polynucleotides as provided herein may further be used for the diagnosis and monitoring of ovarian cancer.
L'invention porte sur des compositions et sur des procédés utilisés dans la thérapie et le diagnostic du cancer des ovaires. Ces compositions peuvent comprendre une ou plusieurs protéines du carcinome ovarien, leurs parties immunogènes, des polynucléotides qui codent ces parties ou anticorps ou cellules du système immun spécifiques de ces protéines. Ces compositions peuvent être utilisées, par exemple, dans la prévention et le traitement des maladies telles que le cancer des ovaires. L'invention porte également sur des procédés visant à identifier des antigènes tumoraux qui sont sécrétés par les carcinomes ovariens et/ou d'autres tumeurs. Les polypeptides et les polynucléotides de cette invention peuvent être également utilisés dans le diagnostic et le contrôle continu du cancer des ovaires.
Albone Earl
Algate Paul A.
Carter Darrick
Fanger Gary Richard
Fling Steven P.
Corixa Corporation
Gowling Lafleur Henderson Llp
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