Compositions and methods for the treatment and clinical...

Details Compositions and methods for the treatment and clinical... Compositions and methods for the treatment and clinical...

A - Human Necessities

01

N

A01N 61/00 (2006.01) A61K 31/00 (2006.01) A61K 39/002 (2006.01) A61K 39/005 (2006.01) A61K 39/008 (2006.01) A61K 45/00 (2006.01) A61K 47/00 (2006.01)

Patent

CA 2555612

A treatment for psoriasis and related maladies has a mechanism of action that includes an inhibition or blockade of T cell rolling by interference with the CLA-E selectin interaction and interference of endothelial binding or diapadesis by induced by blocking the LFA-1/ICAM interaction and/or the VLA/VCAM interaction with endothelial cells.

L'invention concerne un traitement du psoriasis et de maladies connexes dont le mécanisme d'action consiste notamment en une inhibition ou un blocage du roulement des lymphocytes T par interférence avec l'interaction de la CLA-E sélectine et l'interférence de liaison endothéliale ou de la diapédèse par blocage de l'interaction LFA-1/ICAM et/ou l'interaction VLA/VCAM avec des cellules endothéliales.

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