C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A61K 38/17 (2006.01) A61K 39/00 (2006.01) C07H 21/04 (2006.01) C07K 14/15 (2006.01) C07K 14/47 (2006.01) C07K 14/82 (2006.01) C07K 16/32 (2006.01) C12N 5/10 (2006.01) C12N 15/66 (2006.01) C12Q 1/68 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2286348
Compositions and methods for the detection and therapy of breast cancer are disclosed. The compounds provided include nucleotide sequences that are preferentially expressed in breast tumor tissue, as well as polypeptides encoded by such nucleotide sequences. Vaccines and pharmaceutical compositions comprising such compounds are also provided and may be used, for example, for the prevention and treatment of breast cancer. The polypeptides may also be used for the production of antibodies, which are useful for diagnosing and monitoring the progression of breast cancer patient.
L'invention a trait à des compositions et aux méthodes afférentes permettant de déceler un carcinome mammaire et de le traiter. Les composés de l'invention comportent des séquences nucléotidiques exprimées, de préférence, dans le tissu de la tumeur mammaire, ainsi que des polypeptides codés par ces séquences nucléotidiques. Elle concerne également des vaccins et des compositions pharmaceutiques renfermant ces composés et que l'on utilisera aux fins de la prophylaxie et de la thérapie du carcinome mammaire. Il est également possible d'utiliser ces polypeptides pour la production d'anticorps, utiles en matière de diagnostic et s'agissant de surveiller la progression du carcinome mammaire chez une patiente.
Frudakis Tony N.
Reed Steven G.
Smith John M.
Corixa Corporation
Gowling Lafleur Henderson Llp
LandOfFree
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