A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) C07K 16/00 (2006.01) C12P 21/08 (2006.01)
Patent
CA 2627427
The present invention relates to compositions and methods for the treatment of diseases and conditions, including ocular diseases and conditions, characterized by aberrant fibrogenesis or scarring, inflammation and/or aberrant neovascularization or angiogenesis. The compositions and methods of the invention utilize immune-derived moieties that are specifically reactive against bioactive lipids and which are capable of decreasing the effective concentration of the bioactive lipids. In some embodiments, the immune-derived moiety is a monoclonal antibody that is reactive against sphinxine- 1 - phosphate (SlP) or lysophosphophatidic acid (LPA).
La présente invention concerne des compositions et des méthodes de prévention et de traitement de maladies et de pathologies, comprenant les maladies et les pathologies oculaires caractérisées par une fibrogenèse ou une cicatrisation aberrante, une inflammation et/ou une néovascularisation ou angiogenèse aberrantes. Les compositions et les méthodes selon l'invention comprennent des fractions d'origine immune qui sont spécifiquement réactives contre les lipides bioactifs et qui sont capables de réduire la concentration effective dudit lipide bioactif. Dans certaines formes de réalisation, la fraction d'origine immune est un anticorps monoclonal qui est réactif contre la sphingosine-1-phosphate (SlP) ou l'acide lysophosphatidique (LPA).
Garland William A.
Sabbadini Roger A.
Stoller Glenn L.
Borden Ladner Gervais Llp
Garland William A.
Lpath Inc.
Sabbadini Roger A.
Stoller Glenn L.
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