A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/47 (2006.01) A61K 31/445 (2006.01) A61K 31/454 (2006.01) A61K 31/4745 (2006.01) A61K 31/7056 (2006.01) A61K 31/724 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2408707
This invention relates to compositions comprising thalidomide and another anti- cancer drug which can be used in the treatment or prevention of cancer. Preferred anti-cancer drugs are topoisomerase inhibitors. A particular composition comprises thalidomide, or a pharmaceutically acceptable salt, solvate, or clathrate thereof, and irinotecan. The invention also relates to methods of treating or preventing cancer which comprise the administration of a thalidomide and another anti-cancer drug to a patient in need of such treatment or prevention. The invention further relates to methods of reducing or avoiding adverse side effects associated with the administration of chemotherapy or radiation therapy which comprise the administration of thalidomide to a patient in need of such reduction or avoidance.
La présente invention concerne des compositions à base de thalidomide et d'un autre médicament anticancéreux pouvant être utilisés dans le traitement ou la prévention du cancer. Les médicaments anticancéreux préférés sont des inhibiteurs de la topoisomérase. Une composition particulière renferme de la thalidomide, ou un sel acceptable sur le plan pharmaceutique, un solvate, ou un clathrate de ceux-ci, et de l'irinotecan. Par ailleurs, cette invention concerne des méthodes de traitement ou de prévention du cancer, consistant à administrer à un patient un thalidomide et un autre médicament anticancéreux. Cette invention concerne également des méthodes de réduction ou de prévention des effets secondaires associés à la chimiothérapie ou à la radiothérapie qui consistent à administrer de la thalidomide à un patient en vue de réduire ou de prévenir ces effets secondaires.
Barer Sol
Zeitlin Andrew
Zeldis Jerome B.
Celgene Corp.
Smart & Biggar
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