Compositions and methods for the treatment of cystic fibrosis

Details Compositions and methods for the treatment of cystic fibrosis Compositions and methods for the treatment of cystic fibrosis

A - Human Necessities

61

K

A61K 31/19 (2006.01) A61K 31/00 (2006.01) A61K 31/165 (2006.01) A61K 31/191 (2006.01) A61K 31/192 (2006.01) A61K 31/194 (2006.01) A61K 31/216 (2006.01) A61K 31/22 (2006.01) A61P 5/48 (2006.01) A61P 11/00 (2006.01)

Patent

CA 2324426

The invention is directed to novel pharmaceutical compositions comprising chemical agents that are useful in the treatment and prevention of cystic fibrosis and the prevention of signs and symptoms of this disease. These pharmaceutical compositions are surprisingly successful in the treatment of disorders related to cystic fibrosis including disorders of blood production. Many of these compositions of the invention are even more effective when administered to a patient in pulses. Pulse therapy is not a form of discontinuous administration of the same amount of a composition over time, but comprises administration of the same dose of the composition at a reduced frequency or administration of reduced doses.

L'invention concerne de nouvelles compositions pharmaceutiques comprenant des agents chimiques utiles dans le traitement et la prévention de la mucoviscidose, et la prévention des signes et des symptômes de cette maladie. Ces compositions pharmaceutiques sont étonnamment efficaces dans le traitement de troubles en rapport avec la mucoviscidose y compris les troubles de production du sang. La plupart de ces compositions sont encore plus efficaces lorsqu'elles sont administrées à un patient sous forme de corticothérapie à doses fortes, en perfusions intraveineuses rapides. La corticothérapie n'est pas une forme d'administration discontinue de la même dose d'une composition pendant un certain temps, mais elle comprend l'administration cette même dose de la composition, à une fréquence réduite ou l'administration de doses réduites.

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