C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 303/00 (2006.01) C07C 35/08 (2006.01) C07C 35/12 (2006.01) C07C 69/76 (2006.01) C07C 69/95 (2006.01) C07C 321/00 (2006.01) C07D 345/00 (2006.01)
Patent
CA 2535265
Provided are small-molecule Trp-p8 modulators, including Trp-p8 agonists and Trp-p8 antagonists, and compositions comprising small-molecule Trp-p8 agonists as well as methods for identifying and characterizing novel small-molecule Trp- p8 modulators and methods for decreasing viability and/or inhibiting growth of Trp-p8 expressing cells, methods for activating Trp-p8-mediated cation influx, methods for stimulating apoptosis and/or necrosis, and related methods for the treatment of diseases, including cancers such as lung, breast, colon, and/or prostate cancers as well as other diseases, such as benign prostatic hyperplasia, that are associated with Trp-p8 expression.
La présente invention concerne des modulateurs Trp-p8 de petites molécules, comprenant des agonistes Trp-p8 et des antagonistes Trp-p8, parmi lesquels des agonistes Trp-p8 de petites molécules, ainsi que des procédés permettant d'identifier et de caractériser des nouveaux modulateurs Trp-p8 de petites molécules, ainsi que des méthodes permettant de réduire la viabilité et/ou d'empêcher la croissance des cellules exprimant le Trp-p8. Cette invention concerne également des méthodes permettant d'activer l'influx cationique induit par Trp-p8, des méthodes permettant de stimuler l'apoptose et/ou la nécrose, et des méthodes associées permettant de traiter des maladies, parmi lesquelles les cancers, tels que les cancers du poumon, du sein, du colon et/ou de la prostate, ainsi que d'autres maladies, telles que l'hyperplasie prostatique bénigne, qui sont associées à l'expression de Trp-p8.
Chen Feng
Duncan David
Graddis Thomas J.
Laus Reiner
Moreno Ofir
Dendreon Corporation
Smart & Biggar
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