C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) A61K 6/00 (2006.01) A61K 31/7088 (2006.01) A61K 48/00 (2006.01) C12Q 1/04 (2006.01)
Patent
CA 2494908
Compounds, compositions, and pharmaceutical compositions comprising oligonucleotides capable of disrupting protein aggregations that are characteristic of disorders of protein assembly are described, as are in vitro and in vivo methods for identifying usch oligonucleotides, and methods for treating such disorders by administration of such compositions.
L'invention concerne des composés, des compositions et des compositions pharmaceutiques contenant des oligonucléotides capables d'interrompre des agrégations de protéines caractéristiques de maladies d'assemblage de protéines. L'invention concerne également des procédés d'identification <i>in vitro</i> et <i>in vivo</i> de tels oligonucléotides, ainsi que des procédés de traitement de tels maladies par administration desdites compositions.
Kmiec Eric B.
Parekh-Olmedo Hetal
Smart & Biggar
University Of Delaware
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