Compositions and methods for the treatment of muscle wasting

A - Human Necessities – 61 – K

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A61K 48/00 (2006.01) A61K 31/7088 (2006.01) A61K 31/7115 (2006.01) A61P 21/00 (2006.01) C07H 21/00 (2006.01) C12N 15/18 (2006.01)

Patent

CA 2558160

The invention provides compositions of oligonucleotides targeted at genes involved in muscle wasting and/or muscle growth. In some embodiments, the oligonucleotides are modified. In some embodiments, the compositions contain one, or more than one, oligonucleotide. The invention also provides methods and kits using the compositions of the invention for the treatment of muscle wasting conditions and/or the promotion of muscle growth. -63-

L'invention concerne des compositions d'oligonucléotides ciblées sur des gènes impliqués dans l'atrophie musculaire et/ou la croissance musculaire. Dans certaines formes d'exécution, les oligonucléotides sont modifiés. Dans des variantes d'exécution, les compositions contiennent un oligonucléotide, ou plus d'un oligonucléotide. L'invention concerne également des procédés et des kits utilisant les compositions de l'invention pour le traitement des états d'atrophie musculaire et/ou pour le développement de la croissance musculaire.

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