Compositions and methods for the treatment of ocular...

A - Human Necessities – 61 – K

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A61K 38/44 (2006.01) A61P 9/10 (2006.01) A61P 27/02 (2006.01)

Patent

CA 2729605

Oxidative damage contributes to cone cell death in retinitis pigmentosa and death of rods, cones, and retinal pigmented epithelial (RPE) cells in ocular oxidative stress related diseases including age-related macular degeneration and retinitis pigmentosa. Oral antioxidants may provide modest benefits, but more efficient ways of preventing oxidative damage are needed. Compositions and methods are provided herein for the prevention, amelioration, and/ or treatment of early or late stage ocular disease by increasing the expression or activity of one or more peroxidases in cells of the eye, particularly retinal cells, and further optionally increasing the expression or activity of one or more superoxide dismuatases in the same cells.

Linvention concerne des compositions et procédés pour le traitement du stress oxydatif oculaire et de la rétinite pigmentaire. Les dommages oxydatifs contribuent à la mort des cônes rétiniens dans la rétinite pigmentaire et à la mort des bâtonnets, des cônes et des cellules de lépithélium pigmentaire rétinien (RPE) dans les maladies associées au stress oxydatif oculaire, y compris la dégénérescence maculaire liée à lâge et la rétinite pigmentaire. Les antioxydants oraux peuvent fournir des bénéfices modestes, mais des procédés plus efficaces de prévention des dommages oxydatifs sont nécessaires. Linvention concerne des compositions et des procédés pour la prévention, lamélioration et/ou le traitement de maladies oculaires à un stade précoce ou tardif par augmentation de lexpression ou de lactivité dune ou de plusieurs peroxydases dans les cellules de lil, notamment les cellules rétiniennes, et également éventuellement par augmentation de lexpression ou de lactivité dune ou de plusieurs superoxyde dismutases dans les mêmes cellules.

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