C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 39/395 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 15/11 (2006.01) C12N 15/62 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2353775
The invention concerns compositions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based upon the identification of genes that are amplified in the genome of tumor cells. Such gene amplification is expected to be associated with the overexpression of the gene product as compared to normal cells of the same tissue type and contribute to tumorigenesis. Accordingly, the proteins encoded by the amplified genes are believed to be useful targets for the diagnosis and/or treatment (including prevention) of certain cancers, and may act as predictors of the prognosis of tumor treatment. The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
L'invention concerne des compositions et des methodes de diagnostic et de traitement d'une croissance ou d'une prolifération cellulaire néoplastique chez un mammifère, notamment chez l'humain. L'invention est fondée sur l'identification de gènes amplifiés dans le génome de cellules tumorales. Cette amplification génique est censée s'accompagner de la surexpression du produit génique par comparaison avec des cellules normales provenant du même type de tissu, et contribue à l'action cancérigène. En conséquence, les protéines codées par les gènes amplifiés sont réputées être des cibles utiles pour le diagnostic et/ou le traitement (y compris la prévention) de certains cancers, et peuvent agir comme prédicteurs du pronostic d'un traitement anticancéreux. L'invention concerne également de nouveaux polypeptides et des molécules d'acide nucléique codant ces polypeptides. Elle concerne en outre des vecteurs et des cellules hôtes comprenant lesdites séquences d'acide nucléique, des molécules polypeptidiques chimères comprenant les polypeptides fusionnés à des séquences polypeptidiques hétérologues, des anticorps se liant aux polypeptides, et des méthodes de production des polypeptides de l'invention.
Botstein David
Goddard Audrey
Gurney Austin L.
Hillan Kenneth
Lawrence David A.
Dennison Associates
Genentech Inc.
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