A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/36 (2006.01) A61K 38/06 (2006.01) A61K 38/19 (2006.01) A61K 38/48 (2006.01) A61K 39/395 (2006.01) C07K 16/40 (2006.01)
Patent
CA 2191065
The invention concerns a method for inhibiting the growth and/or causing regression of tumors by administering a therapeutically effective dose of a procoagulant and a cytokine, preferably TNF-.beta., TNF-.alpha. and/or IL-1. In a specific aspect, the invention concerns a method for tumor treatment by the administration of a therapeutically effective amount of a thrombomodulin inhibitor and a cytokine. The invention also concerns thrombomodulin inhibitors and pharmaceutical compositions used in the course of these treatments.
L'invention concerne un procédé permettant d'inhiber la croissance de tumeurs et/ou de les faire régresser par administration d'une dose d'un procoagulant et d'une cytokine, de préférence de facteur de nécrose tumorale .beta., facteur de nécrose tumorale .alpha. et/ou d'interleukine 1. Selon un aspect spécifique, l'invention concerne un procédé de traitement de tumeurs par administration d'une dose thérapeutiquement efficace d'un inhibiteur de thrombomoduline et d'une cytokine. L'invention concerne également des inhibiteurs de thrombomoduline et des compositions pharmaceutiques utilisées dans ces traitements.
Vehar Gordon A.
Dennison Associates
Genentech Inc.
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