Compositions and methods for the treatment of tumors

Details Compositions and methods for the treatment of tumors Compositions and methods for the treatment of tumors

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07K 14/705 (2006.01) C12N 15/13 (2006.01) C12N 15/63 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2378182

The invention concerns compositions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based upon the identification of an ADAM8 gene that is amplified in the genome of tumor cells. Such gene amplification is associated with the overexpression of the gene product as compared to normal cells of the same tissue type and contributes to tumorigenesis. Accordingly, the ADAM8 protein encoded by the amplified gene is a useful target for the diagnosis and/or treatment (including prevention) of certain cancers, and acts as a predictor of the prognosis of tumor treatment.

L'invention concerne des compositions et procédés de diagnostic et de traitement de la croissance et prolifération cellulaires néoplasiques chez les mammifères, notamment chez l'homme. L'invention se base sur l'identification d'un gène ADAM8, amplifié dans le génome des cellules tumorales, une telle amplification génique étant associée à une surexpression du produit génique, par comparaison avec des cellules normales du même type de tissu, et contribuant à la tumorigenèse. En conséquence, la protéine ADAM8, codée par le gène amplifié, constitue une cible utile dans le diagnostic et/ou le traitement (y compris la prévention) de certains cancers, et elle agit en tant qu'indicateur du pronostic de traitement de la tumeur.

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