Compositions and methods for the treatment of viral infections

Details Compositions and methods for the treatment of viral infections Compositions and methods for the treatment of viral infections

C - Chemistry, Metallurgy

07

K

C07K 14/16 (2006.01)

Patent

CA 2713089

The invention provides compositions, kits and methods utilizing polypeptides having a viral alpha-helix heptad re-peat domain in a stabilized .alpha.-helical structure (herein also referred to as SAH). The compositions are useful for treating and/or preventing viral infections. The invention is based, at least in part, on the result provided herein demonstrating that viral hydrocar-bon stapled alpha helical peptides display excellent proteolytic, acid, and thermal stability, restore the native alpha- helical struc-ture of the peptide, are highly effective in interfering with the viral fusogenic process, and possess superior pharmacokinetic prop-erties compared to the corresponding unmodified peptides.

Cette invention concerne des compositions, des kits et des méthodes utilisant des polypeptides à domaine viral « heptad repeat » alpha-hélicoïdal dans une structure stabilisée a-hélicoïdale (SAH). Les compositions sont utilisées pour traiter et/ou prévenir les infections virales. Linvention repose, au moins en partie, sur le résultat obtenu ici et démontrant que les peptides viraux alpha hélicoïdaux à insertion hydrocarbonée présentent une excellente stabilité protéolytique, acide et thermique, restituent la structure native alpha-hélicoïdale du peptide, sont extrêmement efficaces pour interférer avec le processus fusogène viral, et possèdent des propriétés pharmacocinétiques supérieures par rapport aux peptides non modifiés correspondants.

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