Compositions and methods for therapeutic treatment

Details Compositions and methods for therapeutic treatment Compositions and methods for therapeutic treatment

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 31/704 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01) A61K 47/48 (2006.01) A61K 51/00 (2006.01) C07K 16/30 (2006.01)

Patent

CA 2491427

The present invention relates to compositions utilizing an agent and an antibody, or fragment thereof. In these compositions, the agents, including agents such as anti-cancer, anti-metastasis, anti-leukemia, anti-disease, anti- adhesion, anti-thrombosis, anti -restenosis, anti-autoimmune, anti- aggregation, anti-bacterial, anti-viral, and anti-inflammatory agents, can be complexed or combined with or conjugated to the antibodies, or fragments thereof. In addition, the agent and/or the antibody, or fragment thereof, can be present in the composition in a sub-clinical amount, which is an amount that is less than the amount of the agent generally found to be clinically effective when the agent is administered alone. Preferably, in these compositions of the present invention, the agent is an anthracycline or a derivative thereof, e.g., doxorubicin (adriamycin) or a derivative thereof.

L'invention concerne des compositions faisant intervenir un agent et un anticorps, ou un fragment dudit anticorps. Dans ces compositions, les agents, notamment des agents anti-canc~reux, anti-m~tastases, anti-leuc~miques, anti-maladies, anti-adh~rents, anti-thromboses, anti-rest~noses, anti-maladies auto-immunes, anti-aggr~gants, anti-bact~riens, anti-viraux et anti-inflammatoires, peuvent Útre complex~s ou combin~s aux anticorps ou conjugu~s ~ ceux-ci, ou ~ des fragments de ceux-ci. En outre, l'agent et/ou l'anticorps, ou le fragment de celui-ci, peut Útre pr~sent dans la composition ~ une quantit~ sous-clinique, qui est une quantit~ inf~rieure ~ la quantit~ de l'agent g~n~ralement efficace sur le plan clinique lorsque cet agent est administr~ seul. De pr~f~rence, dans ces compositions, l'agent est un agent anthracycline ou un d~riv~ de celui-ci, par exemple de la doxorubicine (adriamycin) ou un d~riv~ de celle-ci.

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