C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 15/11 (2006.01) C12N 15/62 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2354156
Compositions and methods for the therapy and diagnosis of cancer, such as ovarian cancer, are disclosed. Compositions may comprise one or more ovarian carcinoma proteins, immunogenic portions thereof, polynucleotides that encode such portions or antibodies or immune system cells specific for such proteins. Such compositions may be used, for example, for the prevention and treatment of diseases such as ovarian cancer. Methods are further provided for identifying tumor antigens that are secreted from ovarian carcinomas and/or other tumors. Polypeptides and polynucleotides as provided herein may further be used for the diagnosis and monitoring of ovarian cancer.
L'invention concerne des compositions et des procédés destinés à la thérapie et au diagnostic de cancers tels que le cancer de l'ovaire. Les compositions peuvent comprendre une ou plusieurs protéines du carcinome de l'ovaire, leurs parties immunogéniques, des polynucléotides codant pour ces parties ou des anticorps ou des cellules du système immunitaire spécifique à ces protéines. Ces compositions peuvent s'utiliser, par exemple, dans la prévention et le traitement de maladies telles que le cancer de l'ovaire. L'invention concerne en outre des procédés pour identifier les antigènes tumoraux sécrétés depuis les carcinomes de l'ovaires et/ou d'autres tumeurs. En outre, les polypeptides et les polynucléotides fournis ici peuvent être utilisés dans le diagnostic et la surveillance du cancer de l'ovaire.
Algate Paul A.
Frudakis Tony N.
King Gordon E.
Mitcham Jennifer L.
Corixa Corporation
Gowling Lafleur Henderson Llp
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