Compositions and methods for therapy and diagnosis of...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 14/52 (2006.01) C07K 14/705 (2006.01) C07K 14/78 (2006.01) C07K 16/18 (2006.01) C12N 5/10 (2006.01) C12N 9/64 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2370482

Compositions and methods for the therapy and diagnosis of cancer, such as head and neck cancer and lung cancer, are disclosed. Compositions may comprise one or more head and neck tumor proteins, immunogenic portions thereof or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a head and neck tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as head and neck cancer and lung cancer. Diagnostic methods based on detecting a head and neck tumor protein, or mRNA encoding such a protein, in a sample are also provided.

L'invention porte sur des compositions et des procédés utilisés en thérapie et dans le diagnostic du cancer, notamment le cancer de la tête et du cou et le cancer des poumons. Ces compositions peuvent comprendre une ou plusieurs protéines tumorales de la tête et du cou, des parties immunogènes ou des polynucléotides codant ces parties. En variante, une composition thérapeutique peut comprendre une cellule présentant un antigène et qui exprime une protéine tumorale de la tête et du cou, ou un lymphocyte T spécifique des cellules exprimant cette protéine. Ces compositions peuvent être utilisées, par exemple, dans la prévention et le traitement de maladies telles que le cancer de la tête et du cou et le cancer des poumons. L'invention porte également sur des procédés diagnostiques basés sur la détection, dans un échantillon, d'une protéine tumorale de la tête et du cou, ou d'un ARNm codant cette protéine.

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