A - Human Necessities – 61 – L
Patent
A - Human Necessities
61
L
A61L 27/54 (2006.01) A61F 2/02 (2006.01) A61F 2/10 (2006.01) A61L 27/38 (2006.01) A61L 27/04 (2006.01) A61L 27/14 (2006.01) A61L 27/22 (2006.01) A61L 27/40 (2006.01) A61L 27/50 (2006.01)
Patent
CA 2684040
Implants for repairing tissue defects, such as cartilage tissue defects, and methods of their preparation and use are disclosed. A mold of a tissue defect is prepared by pressing upon the defect a substrate having shape memory, such as aluminum foil. The mold, which has contours substantially conforming to those of the defect, is removed from the defect, and tissue particles are added to the mold ex vivo. A biological carrier such as biocompatible glue is also added to the mold. The combination of tissue particles and the biological carrier thereby form an implant, which retains its shape after separation from the mold. The implant can be transferred to the tissue defect, with contours of the mold matching corresponding contours of the defect.
L'invention concerne des implants pour réparer des défauts de tissu, tels que des défauts de tissu de cartilage et des procédés pour leur préparation et utilisation. On prépare une empreinte d'un défaut de tissu en pressant sur le défaut un substrat ayant une mémoire de forme, telle qu'une feuille d'aluminium. L'empreinte, qui comporte des contours se conformant sensiblement à ceux du défaut, est retirée du défaut et des particules de tissu sont ajoutées à l'empreinte ex vivo. Un support biologique tel qu'une colle biocompatible est également ajouté à l'empreinte. La combinaison de particules de tissu et du support biologique forme ainsi un implant, qui retient sa forme après séparation de l'empreinte. L'implant peut être transféré sur le défaut de tissu, les contours de l'implant moulé correspondant aux contours du défaut.
Gao Jizong
Walthall Ben
Yao Jian
Zaporojan Victor
Gowling Lafleur Henderson Llp
Isto Technologies Inc.
Zimmer Inc.
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