A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01) A61K 8/99 (2006.01) A61P 17/00 (2006.01) A61Q 19/08 (2006.01)
Patent
CA 2599017
Improved formulations for transdermal delivery of botulinum toxin are disclosed. The formulations include, for example, botulinum toxin non- covalently associated with a positively charged backbone having branching or efficiency groups. The formulations also include a partitioning agent, oligo- bridge, or polyanion bridge, and may optionally contain a viscosity modifying agent. The formulations are designed for topical application onto the skin of a patient and may be used to treat wrinkles, hyperhidrosis, and other health- related problems. Kits for administration are also described.
Formulations améliorées pour la délivrance transdermique de toxine botulinique, qui comprennent, par exemple : toxine botulinique en association non covalente avec une ossature à charge positive dotée de groupes de ramification ou efficaces. Ces formulations comprennent aussi un agent de séparation, un oligo-pont ou un pont polyanionique, et elles peuvent éventuellement comporter un agent modificateur de viscosité. Les formulations en question se prêtent à une application topique sur la peau du patient et on peut les utiliser pour traiter les rides, l'hyperhidrose et d'autres problèmes de santé. L'invention concerne également des kits d'administration.
Dake Michael D.
Waugh Jacob M.
Revance Therapeutics Inc.
Smart & Biggar
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