Compositions and methods for topical application and...

Details Compositions and methods for topical application and... Compositions and methods for topical application and...

A - Human Necessities

61

K

A61K 38/16 (2006.01) A61K 47/42 (2006.01)

Patent

CA 2558408

A composition for topical application of a botulinum toxin (including botulinum toxin derivatives) comprises a botulinum toxin and a carrier comprising a polymeric backbone comprising a long-chain polypeptide or nonpeptidyl polymer having attached positively charged branching or "efficiency" groups. The invention also relates to methods for reducing muscle paralysis and other conditions that may be treated with a botulinum toxin, particularly paralysis of subcutaneous, and most particularly, facial, muscles, by topically applying an effective amount of the botulinum toxin and carrier, in conjunction, to the subject's skin or epithelium. Kits for administration are also described.

L'invention concerne une composition pour une application topique d'une toxine botulinique (notamment des dérivés de toxine botulinique) comprenant une toxine botulinique et un vecteur comprenant un squelette polymère comprenant un polypeptide à chaîne longue ou un polymère non peptidyle présentant une ramification positivement chargée ou un groupe "efficace". L'invention concerne également des méthodes pour réduire une paralysie musculaire ou d'autres troubles pouvant être traités au moyen d'une toxine botulinique, en particulier une paralysie des muscles sous-cutanés et spécialement des muscles faciaux, par une application topique d'une quantité efficace de la toxine botulinique et de son vecteur, conjointement associés, sur la peau ou sur l'épithélium du patient. L'invention concerne également des trousses destinées à une telle administration.

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