C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/00 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2599016
The invention relates to the transdermal application of oligopeptides for reducing synaptic transmission in tissues of an animal. In one aspect, this invention relates to compositions comprising an oligopeptide and optionally a carrier comprising a positively charged "backbone" having positively charged branching or "efficiency" groups, as described herein. Most preferably the positively charged carrier is a long-chain positively charged polypeptide or a positively charged nonpeptidyl polymer, for example, a polyalkyleneimine. The invention further relates methods for producing a biologic effect of reducing synaptic transmission in a tissue by topically applying an effective amount of such a composition, preferably to the skin, of a subject or patient in need of such treatment. This invention also provides kits for preparing or formulating a composition that comprises the oligopeptide and optionally a carrier, as well as such additional items that are needed to produce a usable formulation, or a premix that may in turn be used to produce such a formulation.
L'invention concerne l'application transdermique d'oligopeptides pour réduire la transmission synaptique dans les tissus d'un animal. Dans un aspect, l'invention concerne des compositions comprenant un oligopeptide et éventuellement un porteur comprenant un squelette chargé positivement doté d'une ramification chargé positivement ou des groupes "efficaces". Plus précisément, le porteur chargé positivement est un polypeptide chargé positivement à chaîne longue ou un polymère non peptidyle chargé positivement, par exemple un polyalkylèneimine. L'invention concerne en outre des procédés de production d'un effet biologique de réduction de la transmission synaptique dans un tissu par application topique d'une dose efficace d'une telle composition, de préférence sur la peau, du sujet ou du patient nécessitant un tel traitement. L'invention concerne enfin des trousses de préparation ou de formulation d'une composition comprenant l'oligopeptide et éventuellement un porteur, ainsi que des éléments additionnels nécessaires pour produire une formulation pratique, ou un prémix que l'on peut également utiliser pour produire une telle formulation.
Dake Michael D.
Waugh Jacob M.
Revance Therapeutics Inc.
Smart & Biggar
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