Compositions and methods for topical application of...

A - Human Necessities – 61 – K

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A61K 9/06 (2006.01)

Patent

CA 2265461

The present invention generally relates to pharmaceutical compositions that enable control of drug delivery properties and the development of optimal drug delivery strategies customized for particular drugs and particular diseases. The composition includes a dissolved pharmaceutical that has the capacity to permeate the stratum corneum layer of the epidermis and become available systemically, and pharmaceutical in a microparticulate state that does not readily cross the stratum corneum of the epidermis. The dissolved and microparticulate pharmaceuticals may be the same or different pharmaceuticals. Methods for the preparation and use of the compositions are also provided. In a preferred embodiment, the invention finds particular use in a formulation for the topical application of dapsone for the treatment of acne. In another preferred embodiment, the invention finds particular use for the treatment of herpes lesions.

L'invention porte sur d'une manière générale sur des préparations pharmaceutiques permettant d'ajuster les propriétés de libération de médicaments et de mettre au point des stratégies d'administration optimales propres à certains médicaments et à certaines maladies. Lesdites préparations comportent un produit pharmaceutique dissous capable de pénétrer dans la couche cornée de l'épiderme et d'être disponible de manière systémique, ainsi qu'un produit pharmaceutique à l'état microparticulaire ne traversant pas facilement la couche cornée de l'épiderme. Les préparations pharmaceutiques dissoutes ou microparticulaires peuvent être identiques ou différentes. L'invention porte également sur les procédés d'élaboration et d'utilisation desdites préparations. Dans l'une de ses variantes préférées, l'invention s'applique en particulier à une préparation servant à l'application topique de dapsone pour le traitement de l'acné. Dans une autre variante préférée, elle s'applique en particulier au traitement de lésions herpétiques.

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