Compositions and methods for transdermal oxybutynin therapy

Details Compositions and methods for transdermal oxybutynin therapy Compositions and methods for transdermal oxybutynin therapy

A - Human Necessities

61

K

A61K 31/216 (2006.01) A61F 13/00 (2006.01) A61K 9/06 (2006.01) A61K 9/10 (2006.01)

Patent

CA 2504021

The present invention provides compositions and methods for administering oxybutynin while minimizing the incidence and or severity of adverse drug experiences associated with oxybutynin therapy. In one aspect, these compositions and methods provide a lower plasma concentration of oxybutynin metabolites, such as N-desethyloxybutynin, which is presumed to be contributing at least in part to some of the adverse drug experiences, while maintaining sufficient oxybutynin plasma concentration to benefit a subject with oxybutynin therapy. The invention also provides isomers of oxybutynin and its metabolites that meet these characteristics of minimized incidence and/or severity of adverse drug experiences, and maintenance of beneficial and effective therapy for overactive bladder. In some aspects, the composition may be presented in the form of an unoccluded or free form topically administered gel.

La présente invention concerne des compositions et des procédés d'administration d'oxybutynine permettant de minimiser l'action ou la gravité d'effets indésirables associés à la thérapie par oxybutynine. Dans un mode de réalisation, lesdits compositions et procédés permettent de réduire la concentration de plasma des métabolites d'oxybutynine, tels que N-déséthyloxybutynine, ladite concentration étant supposée jouer au moins partiellement un rôle dans certains effets secondaires, tout en maintenant ladite concentration de plasma d'oxybutynine à un niveau suffisant pour que le patient puisse bénéficier de la thérapie par oxybutynine. L'invention concerne également des isomères d'oxybutynine ainsi que ses métabolites, permettant de minimiser l'action et/ou la gravité d'effets indésirables, et de mettre en oeuvre une thérapie bénéfique et efficace de l'hyperactivité vésicale. Dans certains modes de réalisation, la composition selon l'invention peut se présenter sous la forme d'un gel d'administration topique de forme non-occluse ou libre.

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