Compositions and methods for transport of molecules with...

A - Human Necessities – 61 – K

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A61K 47/48 (2006.01) A61K 31/337 (2006.01) A61K 31/7088 (2006.01) A61K 38/13 (2006.01) C12Q 1/02 (2006.01) G01N 33/50 (2006.01) G01N 33/52 (2006.01)

Patent

CA 2643826

Conjugates of a cargo molecule with a transporter molecule are disclosed, where the cargo molecule and the transporter molecule are linked covalently by a releasable linker. The cargo of the conjugate can be a biologically active agent or a reporter molecule. The transporter modulates the transport of the cargo across a biological barrier (e.g., a cell membrane) compared to the transport of the unconjugated cargo. Releasable linkers suitable for rapid and facile conjugation to various types of cargo and transporters are also disclosed, along with methods for using the linkers in the synthesis of conjugates.

La présente invention concerne des conjugués d'une molécule cargo avec une molécule transporteuse, dans lesquels la molécule cargo et la molécule transporteuse sont liées de manière covalente par un lieur que l'on peut libérer. Le cargo du conjugué peut être un agent biologiquement actif ou une molécule rapporteuse. Le transporteur module le transport du cargo à travers une barrière (par exemple, une membrane cellulaire) par comparaison au transport du cargo non conjugué. La présente invention concerne également des lieurs que l'on peut libérer appropriés pour une conjugaison rapide et facile à divers types de cargos et de transporteurs, ainsi que des procédés d'utilisation de lieurs dans la synthèse de conjugués.

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