A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/573 (2006.01) A61K 9/10 (2006.01) A61K 47/30 (2006.01)
Patent
CA 2545878
Compositions, and methods of using such compositions, useful for injection into the posterior segments of human or animal eyes are provided. Such Compositions include corticosteroid component ~containing particles present in a therapeutically effective amount, a viscosity inducing component, and an aqueous carrier component. The compositions have viscosities of at least about 10 cps or about 100 cps at a shear rate of 0.1/second. In a preferred embodiment, the viscosity is in the range of from about 140,000 cps to about 300,000 cps. The compositions advantageously suspend the particles for prolonged periods of time.
L'invention concerne des compositions et des procédés pour utiliser ces compositions, utilisables à des fins d'injection dans des segments postérieurs d'un oeil animal ou humain. Ces compositions comprennent des particules à composants corticostéroïdes présentes dans des quantités thérapeutiquement efficaces, un composant augmentant la viscosité et un composant d'excipient aqueux. Les compositions ont des taux de viscosité d'au moins environ 10 cps ou d'environ 100 cps avec un taux de cisaillement de 0,1 / sec. Dans un mode de réalisation préféré, la viscosité est comprise entre environ 140,000 cps et environ 300,000 cps. Les compositions suspendent avantageusement les particules pendant des périodes prolongées.
Chang James N.
Lyons Robert T.
Trogden John T.
Whitcup Scott M.
Allergan Inc.
Gowling Lafleur Henderson Llp
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