G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/574 (2006.01) C07K 16/00 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2612021
The present invention relates to compositions and methods for treating, characterizing, and diagnosing cancer. In particular, the present invention provides gene expression profiles and signatures associated with solid tumor stem cells, as well as novel stem cell cancer markers useful for the diagnosis, characterization, prognosis and treatment of solid tumor stem cells. More particularly, the present invention identifies two profiles of cancer stem cells useful for the diagnosis, characterization, and treatment of cancer and cancer metastases. The invention also provides a variety of reagents such as stem cell gene signatures for use in the diagnosis and management of cancer.
La présente invention concerne des compositions et des procédés de traitement permettant de caractériser et de diagnostiquer un cancer. Cette invention concerne en particulier des profils d'expression de gène et des signatures associées à des cellules souches de tumeur solide, ainsi que de nouveaux marqueurs de cancer de cellules souches convenant pour le diagnostic, la caractérisation, le pronostic et le traitement de cellules souches de tumeurs solides. Cette invention concerne plus particulièrement l'identification de deux profils de cellules souches cancéreuses qui convient pour le diagnostic, la caractérisation et le traitement du cancer et de métastases cancéreuses. Cette invention concerne aussi une variété de réactifs tels que des signatures de gène de cellule souche destinées au diagnostic et à la gestion du cancer.
Clarke Michael F.
Gurney Austin L.
Lewicki John A.
Wang Xinhao
Clarke Michael F.
Gurney Austin L.
Lewicki John A.
Oncomed Pharmaceuticals Inc.
Smart & Biggar
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