A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/765 (2006.01) A61P 21/00 (2006.01)
Patent
CA 2708761
The present invention relates to compositions and methods for treating and preventing skeletal muscle deficiencies. In particular, the present invention provides compositions comprising poloxamers (e.g., poloxamer 188 - P188) and methods of using the same for treating and preventing skeletal muscle deficiencies and injuries (e.g., dystrophin-deficient skeletal muscle; skeletal muscle having a contraction force deficit; skeletal muscle having a Ca2+ imbalance; skeletal muscle having microtears).
La présente invention concerne des compositions et des méthodes pour le traitement et la prévention de déficiences des muscles squelettiques. En particulier, la présente invention procure des compositions qui comprennent des poloxamères (par ex., poloxamère 188 - P188), ainsi que des méthodes pour les utiliser pour le traitement ou la prévention de déficiences et de blessures des muscles squelettiques (par ex., carence en dystrophine des muscles squelettiques, muscle squelettique présentant un manque de force de contraction, muscle squelettique ayant un déséquilibre de Ca2+, muscle squelettique présentant des microdéchirures).
Markham Bruce
Metzger Joseph M.
Ng Rainer
Reeve Lorraine
Phrixus Pharmaceuticals Inc.
Smart & Biggar
The Regents Of The University Of Michigan
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