A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/112 (2006.01) A61K 39/00 (2006.01) A61K 39/02 (2006.01) A61K 39/095 (2006.01) A61K 39/10 (2006.01) A61K 39/102 (2006.01) A61K 39/106 (2006.01) A61K 39/108 (2006.01) A61K 48/00 (2006.01) A61P 31/04 (2006.01) A61P 37/00 (2006.01) C12N 1/20 (2006.01) C12N 1/21 (2006.01) C12N 1/36 (2006.01) C12N 15/74 (2006.01) G01N 33/02 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01)
Patent
CA 2359469
The present invention is directed towards vaccine compositions containing pathogenic bacteria such as Salmonella having non-reverting genetic mutations which alter activity of DNA adenine methylase (Dam) and methods using these compositions to elicit an immune response. The invention also provides methods for preparing vaccines as well as screening methods to identify agents which may have anti-bacterial activity.
La présente invention concerne des compositions de vaccins contenant des bactéries pathogènes, telles que la Salmonellose, subissant des mutations génétiques sans réversion qui altèrent l'activité de la méthylase d'adénine de l'ADN (Dam), et des méthodes dans lesquelles ces compositions sont utilisées afin de produire une réponse immunitaire. L'invention concerne également des méthodes de préparation de vaccins ainsi que des méthodes de recherche visant à identifier des agents pouvant avoir une activité antibactérienne.
Heithoff Douglas M.
Low David A.
Mahan Michael J.
Sinsheimer Robert L.
Borden Ladner Gervais Llp
The Regents Of The University Of California
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