Compositions and methods for treating cancers and pathogen...

Details Compositions and methods for treating cancers and pathogen... Compositions and methods for treating cancers and pathogen...

C - Chemistry, Metallurgy

12

N

C12N 5/10 (2006.01) A61K 35/14 (2006.01) A61K 39/385 (2006.01) C07K 14/705 (2006.01) C07K 14/77 (2006.01) C12N 15/62 (2006.01) C12N 15/87 (2006.01) C12Q 1/02 (2006.01) G01N 33/554 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01)

Patent

CA 2253632

Disclosed are cells and methods for treating or preventing tumor formation or infections with pathogens in a patient. The cells of the invention are antigen-presenting cells (e.g., dendritic cells or macrophage) that have been loaded with RNA derived from tumors or pathogens. By administering the RNA-loaded antigen-presenting cells to a patient, tumor formation or pathogen infections can be treated or prevented. Alternatively, the RNA-loaded cells can be used as stimulator cells in the ex vivo expansion of CTL. Such CTL can then be used in a variation of conventional adoptive immunotherapy techniques.

Cellules et procédés destinés à traiter ou à prévenir la formation des tumeurs ou les infections par pathogènes chez un patient. Les cellules selon l'invention sont des cellules présentatrices d'antigènes (p. ex. des cellules dendritiques ou des macrophages) qui ont été chargées d'ARN dérivé de tumeurs ou de pathogènes. La formation des tumeurs ou les infections par pathogènes peuvent être traitées ou prévenues grâce à l'administration au patient de cellules présentatrices d'antigènes chargées d'ARN. Selon une variante, les cellules chargées d'ARN peuvent être utilisées comme cellules stimulatrices dans l'expansion ex vivo de lymphocytes T cytotoxiques (CTL). Ces CTL peuvent être utilisés dans une variante des techniques immunothérapeutiques adoptives conventionnelles.

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