Compositions and methods for treating cardiac dysfunction

A - Human Necessities – 61 – K

Patent

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Details

A61K 48/00 (2006.01) A61N 1/362 (2006.01) C07K 14/705 (2006.01) C12N 5/10 (2006.01)

Patent

CA 2533858

Disclosed are methods and systems for restoring cardiac function or preventing cardiac dysfunction, particularly cardiac pacing dysfunction by genetic modification of the conduction system of the heart. In one embodiment, the invention provides a method of genetically modifying the cells by delivering to the cells one or more coding sequences in a genetic construct capable of modifying the expression of or conductance of ion channels of the cells of the atrioventricular node cells to suppress conductance of impulses therethrough in combination with pacemaker treatment.

La présente invention a trait à des procédés et des systèmes pour la restauration de la fonction cardiaque ou la prévention de dysfonctionnement cardiaque, notamment le dysfonctionnement de stimulation cardiaque par la modification génétique du système de conduction du coeur. Dans un mode de réalisation, l'invention a trait à un procédé de modification génétique des cellules par l'administration dans les cellules d'une ou de plusieurs séquences codantes dans une construction génétique capable de modifier l'expression ou la conductance de canaux ioniques des cellules des cellules du noeud auriculo-ventriculaire pour la suppression de conductance d'impulsions à travers celles-ci en combinaison avec un traitement de stimulateur cardiaque.

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