A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/05 (2006.01) A61K 31/10 (2006.01) A61K 31/105 (2006.01) A61K 45/06 (2006.01) A61P 9/00 (2006.01) A61P 9/10 (2006.01)
Patent
CA 2415624
The present invention relates compositions and methods for the prophylactic or therapeutic treatment of cardiovascular diseases, particularly restenosis and atherosclerosis. These compositions comprise an effective promotor of re- endothelialization, preferably probucol or an analogue thereof, and an inhibitor of lipoprotein oxidation, preferably a probucol-derived bisphenol. Alternatively, the said compositions may comprise a compound that possesses both re-endothelialisation-promoting and lipoprotein oxidation-inhibitory effects. This invention further relates to compositions and methods for promoting re-endothelialization.
L'invention concerne des compositions et des procédés prophylactiques et thérapeutiques de maladies cardio-vasculaires, en particulier, la resténose et l'athérosclérose. Ces compositions comprennent un promoteur efficace de reconstitution de l'endothélium, de préférence, probucol ou un de ses analogues, ainsi qu'un inhibiteur de l'oxydation des lipoprotéines, de préférence, un bisphénol dérivé de probucol. Dans un autre mode de réalisation, ces compositions peuvent contenir un composé exerçant à la fois un effet de promotion de la reconstitution de l'endothélium et d'inhibition de l'oxydation des lipoprotéines. Elle concerne, de plus, des compositions et des procédés servant à promouvoir la reconstitution de l'endothélium.
Blake Cassels & Graydon Llp
The Heart Research Institute Limited
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