Compositions and methods for treating coagulation related...

Details Compositions and methods for treating coagulation related... Compositions and methods for treating coagulation related...

A - Human Necessities

61

K

A61K 39/40 (2006.01) A61K 39/395 (2006.01) A61K 39/42 (2006.01) C07K 16/00 (2006.01) C12P 21/08 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2530980

Disclosed are methods for preventing or treating sepsis, a sepsis-related condition or an inflammatory disease in a mammal. In one embodiment, the method includes administering to the mammal a therapeutically effective amount of at least one humanized antibody, chimeric antibody, or fragment thereof that binds specifically to tissue factor (TF) to form a complex in which factor X or factor IX binding to the complex is inhibited and the administration is sufficient to prevent or treat the sepsis in the mammal. The invention has a wide spectrum of useful applications including treating sepsis, disorders related to sepsis, and inflammatory diseases such as arthritis.

L'invention concerne des procédés pour la prévention ou le traitement d'états infectieux, de troubles liés à ces états ou de maladies inflammatoires chez un mammifère. Selon une variante, on décrit un procédé qui consiste à administrer au mammifère une quantité, efficace du point de vue thérapeutique, d'au moins un anticorps humanisé, un anticorps chimère, ou un fragment correspondant se liant spécifiquement avec le facteur tissulaire pour former un complexe, dans lequel le facteur X ou le facteur IX qui se lie avec ledit complexe est inhibé, et sachant que l'administration est suffisante pour prévenir ou traiter l'état infectieux considéré chez le mammifère. Il existe un large éventail d'applications utiles, y compris le traitement des états infectieux, des troubles liés aux états infectieux et des maladies inflammatoires du type arthrite.

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