C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/52 (2006.01) C12N 9/20 (2006.01)
Patent
CA 2637262
A drug product comprising a combination of highly purified collagenase I and collagenase II from Colostridium histolyticum is disclosed. The drug product includes collagenase I and collagenase II in a ratio of about 1 to 1, with a purity of greater than at least 95%. The invention further disclosed improved fermentation and purification processes for preparing the said drug product.
L'invention concerne une association de collagénase I et de collagénase II issues de clostridium hystolyticum et éminemment purifiées. Le médicament se compose de collagénase I et de collagénase II selon un rapport 1 pour 1, avec une pureté supérieure à au moins 95 %. En outre, l'invention concerne une fermentation améliorée et des procédés de purification destinés à préparer ledit médicament.
Bassett Phillip J.
Del Tito Benjamin J. Jr.
Hitchcock Antony G.
Sabatino Gregory L.
Tharia Hazel A.
Auxilium International Holdings Inc.
Gowling Lafleur Henderson Llp
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