Compositions and methods for treating fibrotic disorders

A - Human Necessities – 61 – K

Patent

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Details

A61K 39/395 (2006.01) A61K 31/7088 (2006.01) A61K 39/17 (2006.01) A61P 1/16 (2006.01) A61P 11/00 (2006.01) A61P 17/02 (2006.01) A61P 43/00 (2006.01) A61K 38/20 (2006.01)

Patent

CA 2595786

The invention provides methods and compositions for reducing or preventing fibrosis in a subject suffering from a fibrotic disorder by administering a therapeutically effective amount of at least one antagonist to the cytokine thymic stromal lymphopoietin to the subject. In one embodiment, the methods and compositions further comprise administering at least one additional antagonist to an additional profibrotic cytokine, growth factor or chemokine.

La présente invention a trait à des procédés et des compositions permettant la réduction ou la prévention de fibrose chez un sujet atteint d'un trouble fibrotique par l'administration d'une quantité thérapeutiquement efficace d'au moins un antagoniste à la lymphopoïétine stromale thymique de cytokine au sujet. Dans un mode de réalisation, les procédés et les compositions de l'invention comprennent également l'administration d'au moins une cytokine profibrotique, un facteur de croissance ou une chimiokine supplémentaire.

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