Compositions and methods for treating gastrointestinal...

A - Human Necessities – 61 – K

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A61K 31/23 (2006.01) A61K 31/20 (2006.01) A61K 31/29 (2006.01) A61P 1/00 (2006.01) A61P 1/12 (2006.01)

Patent

CA 2534124

The disclosure is directed to a method of treating a gastrointestinal condition in a mammal comprising administering a non-glyceryl ester of a long chain fatty acid or a bismuth component and a long chain fatty acid component. The long chain fatty acid ester is selected from the group consisting of lauric acid, lauroleic, myristic, myristoleic, pentadecanoic, palmitic, palmitoleic, margaric, stearic, dihydroxystearic, oleic, ricinoleic, elaidic, linoleic, alpha-linoleic, dihomogamma-linoleic, eleostearic, licanic, arachidonic, arachidic, eicosenoic, eicosapentaenoic, behenic, erucic, docosahexaenoic or lignoceric acid, and mixtures thereof, and the gastrointestinal condition is selected from the group consisting of diarrhea, rapid intestinal transit, dumping syndrom, weight loss, distention, steatorrhea, malnutrition, postgastrectomy syndrom, short bowel syndrom, Chron~s disease, gastrointestinal peptide tumors, irritable bowel syndrom, irritable bowel disease, abdominal pain, abdominal cramping, and combinations thereof. Ethyl alcate is the preferred compound.

L'invention concerne une méthode pour traiter un trouble gastro-intestinal chez un mammifère. Cette méthode consiste à administrer un ester non glycéryle d'un acide gras à chaîne longue ou un composant de bismuth et un composant d'acide gras à chaîne longue. L'ester d'acide gras à chaîne longue est sélectionné dans le groupe comprenant: acide laurique, acide lauroléique, myristique, myristoléique, pentadécanoïque, palmitique, palmitoléique, margarique, stéarique, dihydroxystéarique, oléique, ricinoléique, élaidique, linoléique, alpha-linoléique, dihomogamma-linoléique, éléostéarique, licanique, arachidonique, arachidique, eicosénoïque, écosapentanéoïque, béhénique, érucique, docosahexaénoïque ou lignocérique, et des mélanges de ceux-ci. Le trouble gastrique est sélectionné dans le groupe comprenant: diarrhée, transit intestinal rapide, syndrome de chasse, perte de poids, distension, stéatorrhée, malnutrition, syndrome de post-gastrectomie, syndrome de l'intestin court, maladie de Chrone, tumeurs peptidiques gastro-intestinales, syndrome de l'intestin irritable, maladie de l'intestin irritable, douleurs abdominales, crampes abdominales, et des combinaisons de ceux-ci. Le composé préféré de l'invention est de l'alcate d'éthyle.

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