Compositions and methods for treating heart failure

Details Compositions and methods for treating heart failure Compositions and methods for treating heart failure

C - Chemistry, Metallurgy

07

D

C07D 413/12 (2006.01) A61K 31/167 (2006.01) A61K 31/44 (2006.01) A61K 31/455 (2006.01) A61P 9/00 (2006.01) A61P 9/10 (2006.01) C07D 213/30 (2006.01) C07D 213/36 (2006.01) C07D 213/65 (2006.01) C07D 261/18 (2006.01) C07D 333/38 (2006.01) C07D 401/12 (2006.01) C07D 409/12 (2006.01)

Patent

CA 2470427

Certain substituted benzamide derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.

L'invention concerne certains dérivés substitués de benzamide qui modulent sélectivement le sarcomère cardiaque, par exemple, en stimulant la myosine cardiaque et qui conviennent au traitement de l'insuffisance cardiaque systolique, notamment l'insuffisance cardiaque globale.

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