A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/45 (2006.01) A61K 38/16 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) A61P 35/02 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2761438
The invention relates to modulating the SIRPa-CD47 interaction in order to treat hematological cancer and compounds therefor. In some embodiments, there is provided methods and uses of SIRPa polypeptides, fragments and fusion proteins for treating hematological cancer, preferably human acute myeloid leukemia.
L'invention concerne la modulation de l'interaction SIRPa-CD47 pour traiter un cancer hématologique, ainsi que des composés associés. Certains modes de réalisation concernent des méthodes d'utilisation de polypeptides SIRPa, de fragments et de protéines hybrides dans le traitement d'un cancer hématologique, de préférence la leucémie myéloïde aiguë humaine.
Danska Jayne
Dick John
Jin Liqing
Rajakumar Sujeetha
Theocharides Alexandre
Norton Rose Canada S.e.n.c.r.l.,s.r.l./llp
The Hospital For Sick Children
University Health Network
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