Compositions and methods for treating ischemia and...

Details Compositions and methods for treating ischemia and... Compositions and methods for treating ischemia and...

A - Human Necessities

61

K

A61K 31/385 (2006.01) A61P 9/10 (2006.01)

Patent

CA 2761798

The present invention relates, in some embodiments, to compositions comprising a substantially pure compound represented by Structural Formula (I) and methods of using such compounds to activate cytoprotective kinases. In additional embodiments, the invention relates to methods for treating an ischemia or an ischemia-reperfusion injury in a subject, comprising administering to the subject an effective amount of a compound of the invention (e.g., in multiple doses). The values and preferred values of the variables in Structural Formula (I) are defined herein.

La présente invention concerne, dans certains modes de réalisation, des compositions comprenant un composé sensiblement pur représenté par la formule développée (I) et des procédés d'utilisation de tels composés pour activer des kinases cytoprotectrices. Dans d'autres modes de réalisation, l'invention concerne des procédés de traitement d'une ischémie ou d'une lésion d'ischémie-reperfusion chez un patient, consistant à administrer au patient une quantité efficace d'un composé de l'invention (par exemple en doses multiples). Les valeurs et les valeurs préférées des variables dans la formule développée (I) sont définies ici.

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