C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 295/20 (2006.01) A61K 31/27 (2006.01) A61K 31/34 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) A61K 31/55 (2006.01) C07C 271/34 (2006.01) C07C 279/18 (2006.01) C07D 211/18 (2006.01) C07D 211/26 (2006.01) C07D 243/08 (2006.01) C07D 295/185 (2006.01) C07D 295/215 (2006.01) C07D 493/04 (2006.01)
Patent
CA 2200561
Novel compounds, compositions and methods effective for the prevention and treatment of mast-cell mediated inflammatory disorders are described. The compounds, compositions and methods are effective for the prevention and treatment of inflammatory diseases associated with the respiratory tract, such as asthma and allergic rhinitis, as well as other types of immunomediated inflammatory disorders, such as rheumatoid arthritis, conjunctivitis and inflammatory bowel disease, various dermatological conditions, as well as certain viral conditions. The compounds comprise potent and selective inhibitors of the mast cell protease tryptase. The compositions for treating these conditions include oral, inhalant, topical and parenteral preparations as well as devices comprising such preparations.
L'invention concerne de nouveaux composés, compositions et procédés efficaces pour la prévention et le traitement de maladies inflammatoires provoquées par les mastocytes. Ces composés, compositions et procédés sont efficaces pour la prévention et le traitement de maladies inflammatoires associées aux voies respiratoires, telles que l'asthme et la rhinite allergique, ainsi que d'autres types de maladies inflammatoires d'origine immune, telles que la polyarthrite rhumatoïde, la conjonctivite et les inflammations intestinales, différentes maladies dermatologiques, ainsi que certaines maladies virales. Les composés comprennent des inhibiteurs puissants et sélectifs de la protéase tryptase des mastocytes. Les compositions de traitement de ces maladies comprennent des préparations s'administrant par voie orale, nasale, locale ou parentérale, ainsi que des systèmes contenant lesdites préparations.
Dener Jeffrey M.
Gangloff Anthony R.
Kuo Elaine Yee-Lin
Rice Ken D.
Arris Pharmaceutical Corporation
Axys Pharmaceuticals
Sim & Mcburney
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