C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/00 (2006.01) A61K 31/7088 (2006.01) A61K 41/00 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) A61P 39/00 (2006.01) C07H 21/04 (2006.01) C07K 16/18 (2006.01) C07K 16/40 (2006.01) C12N 9/12 (2006.01) C12N 9/99 (2006.01) C12N 15/11 (2006.01) C07K 14/47 (2006.01) C12N 15/54 (2006.01)
Patent
CA 2410516
Inhibitors of KIAA0175 are provided that reduce the expression or biological activities of KIAA0175, p53 and/or p21 in a mammalian cell. KIAA0175 inhibitors include anti-sense molecules, ribozymes, antibodies and antibody fragments, proteins and polypeptides as well as small molecules. KIAA0175 inhibitors find use in compositions and methods for decreasing KIAA0175, p53 and/or p21 gene expression as well as methods for increasing the chemo and/or radiosensitivity of mammalian cells, including tumor cells, methods for decreasing the side effects of cancer therapy and methods for treating neoplastic diseases.
L'invention concerne des inhibiteurs de KIAA0175 réduisant l'expression ou les activités biologiques de KIAA0175, p53 et/ou p21 dans une cellule mammifère. Ces inhibiteurs de KIAA0175 consistent en des molécules antisens, des ribozymes, des anticorps et des fragments d'anticorps, des protéines et des polypeptides, ainsi qu'en de petites molécules. Ces inhibiteurs de KIAA0175 sont mis en application dans des compositions et des procédés servant à diminuer l'expression des gènes KIAA0175, p53 et/ou p21, et dans des procédés servant à augmenter la sensibilité à la chimiothérapie et/ou aux rayonnements de cellules mammifères, y compris des cellules tumorales, dans des procédés servant à diminuer les effets secondaires de la thérapie du cancer et dans des procédés servant à traiter des maladies néoplasiques.
Seeley Todd W.
Williams Lewis T.
Wu Bin
Borden Ladner Gervais Llp
Chiron Corporation
Novartis Vaccines And Diagnostics Inc.
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