C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/864 (2006.01) A61K 38/18 (2006.01) A61K 48/00 (2006.01) A61P 25/00 (2006.01) C07K 14/475 (2006.01) C12N 15/12 (2006.01)
Patent
CA 2457057
Compositions and methods for treating subjects with preexisting neuronal damage are disclosed. The compositions and methods use adeno-associated virus (AAV)-based gene delivery systems for delivering glial cell line-derived neurotrophic factor (GDNF) to subjects with neurodegenerative conditions such as Parkinson's disease.
La présente invention concerne des compositions et des procédés permettant de traiter des sujets atteints de dommages neuronaux préexistants. Les compositions et procédés de l'invention font appel à des systèmes de délivrance de gènes à base de virus adéno-associés pour délivrer un facteur neurotrophique dérivé d'une lignée de cellules gliales (GDNF) à des sujets souffrant d'états neurodégénératifs tels que la maladie de Parkinson.
Ikeguchi Kunihiko
Muramatsu Shin-Ichi
Nakano Imaharu
Ozawa Keiya
Kirby Eades Gale Baker
Mitsubishi Tanabe Pharma Corporation
Tanabe Seiyaku Co. Ltd.
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