A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 45/08 (2006.01) A61K 31/165 (2006.01) A61K 31/167 (2006.01) A61K 31/216 (2006.01) A61K 31/4375 (2006.01) A61K 31/445 (2006.01) A61K 31/473 (2006.01) A61K 31/495 (2006.01) A61K 31/496 (2006.01) A61K 31/695 (2006.01) A61P 25/00 (2006.01) A61P 35/00 (2006.01) C12Q 1/02 (2006.01)
Patent
CA 2606658
The invention relates to a clonogenic neurosphere assay to carry out high throughput screens (HTS) to identify potent and/or selective modulators of proliferation, differentiation and/or renewal of neural precursor cells, neural progenitor cells and/or self-renewing and multipotent neural stem cells (NSCs). The invention also relates to compositions comprising the identified modulators and methods of using the modulators and compositions, in particular to treat neurological disorders (e.g. brain or CNS cancer) or damage.
Diamandis Phedias
Dirks Peter B.
Tyers Mike
Diamandis Phedias
Dirks Peter B.
Hsc Research And Development Limited Partnership
Mccarthy Tetrault Llp
Mount Sinai Hospital
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