A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 39/42 (2006.01) A61P 27/02 (2006.01) A61P 31/12 (2006.01) A61P 33/02 (2006.01) C07K 16/44 (2006.01)
Patent
CA 2667706
The present invention relates to compositions and methods for prevention and treatment of diseases and conditions, particularly ocular diseases and conditions, characterized by aberrant fibrogenesis or scarring, inflammation, and/or aberrant neovascularization or angiogenesis. The compositions and methods of the invention utilize immune-derived moieties that are specifically reactive against the bioactive lipid, sphingosine-1 -phosphate, and its variants, which moieties are capable of decreasing the effective concentration of bioactive lipid being targeted. In one embodiment, the immune-derived moiety is a humanized monoclonal antibody that is reactive against sphingosine-1 -phosphate.
La présente invention concerne des compositions et des procédés pour la prévention et le traitement de maladies et de troubles, en particulier de maladies et de troubles oculaires, caractérisés par une fibrogenèse ou une cicatrisation aberrante, une inflammation, et/ou une néovascularisation ou angiogenèse aberrante. Les compositions et procédés de l'invention utilisent des fractions issues du système immunitaire qui sont spécifiquement aptes à réagir à l'encontre du lipide bioactif, le sphingosine-1-phosphate, et ses variants, lesquelles fractions sont capables de diminuer la concentration efficace du lipide bioactif qui est ciblé. Dans un mode de réalisation, la fraction issue du système immunitaire est un anticorps monoclonal humanisé qui est apte à réagir à l'encontre du sphingosine-1-phosphate.
Garland William A.
Sabbadini Roger A.
Stoller Glenn L.
Lpath Inc.
Smart & Biggar
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