A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/4196 (2006.01) A61P 9/10 (2006.01)
Patent
CA 2582324
This invention relates to CXCR4 inhibitors and their use in treating and/or preventing a variety of angiogenic, microvascular and ocular disorders including primary indications for diabetic retinopathy, macular degeneration (such as wet or neovascular age-related macular degeneration (AMD) and dry or atrophic AMD), macular edema, and secondary indications for inhibiting tumor vascularization, and corneal and iris neovascularization.
L'invention concerne des inhibiteurs CXCR4 et leur utilisation dans le traitement et/ou la prévention de divers troubles angiogéniques, microvasculaires et oculaires, notamment, des indications primaires de la rétinopathie diabétique, de la dégénérescence maculaire (telle que la dégénérescence maculaire liée à l'âge néovasculaire ou humide et la dégénérescence maculaire atrophique ou sèche), de l'oedème maculaire, et des indications secondaires d'inhibition de la vascularisation tumorale et de la néovascularisation de la cornée et de l'iris.
Sullivan Kathleen A.
Thut Catherine J.
Merck & Co. Inc.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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